FEATURES OF KIDNEY DAMAGE IN CHILDREN WITH OBESITY
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Abstract
The review provides information about the morphology and function of the kidneys in children with obesity. The influence and interrelationship of numerous pathogenetic factors affecting the functioning of the kidney is discussed. The use of early biomarkers of kidney pathology in obesity with an assessment of the level of lipid and carbohydrate metabolism, insulin resistance, serum leptin and adiponectin is promising for diagnosing renal lesions in obesity in children.
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References
Borovkova N.Yu., Borovkov N.N., Teplova N.O. The state of the vasodilating function of the endothelium in arterial hypertension in patients with chronic glomerulonephritis with preserved renal function. Clinical Medicine 2009; (4):57-61
Vyalkova AA, Savelyeva EV, Kulagina EP, Belova MA. Features of kidney pathology in diabetes mellitus and obesity in children. Materials of the conference of pediatric nephrologists, urologists “In memory of A.V. Papaya is dedicated” (St. Petersburg, February 5, 2016).
Vyalkova AA, Nikolaeva SN, Lebedeva EN et al. Characteristics of lipid metabolism in obesity in children with nephropathies. Proceedings of the III scientific and practical conference "Pediatrics and pediatric surgery in the Volga Federal District" (Kazan, 2006); 107-108
Dedov I.I., Shestakova M.V. Diabetic Nephropathy M. "Universum Publishing": 2000.
Dedov I.I., Peterkova V.A. Federal clinical guidelines (protocols) for the management of children with endocrine diseases. M.: Practice, 2014. - 442 p.
Kidney disease and obesity: molecular relationships and new approaches to diagnosis / Vyalkova A.A. et al. / Nephrology. 2017. Volume 21. No. 3, P 25 – 38.
Clinical and pathogenetic aspects of kidney damage in obesity (literature review)./ Vyalkova A.A.// Nephrology 2014; (3): 24-33
Groom EA, Paramonova NS. Clinical features of the course of acute and chronic glomerulonephritis in children with endothelial dysfunction. Journal of GrSMU 2010; (2): 149-151
Kutyrina IM, Krasnova EA, Fedorova EV, Fomin VV. Kidney damage in obesity: clinical, pathogenetic and therapeutic aspects. Doctor 2005; (6):6-9 .
Kholmuradova Zilola Ergashevna, Khaydarova Khaticha Ramizovna, & Ibragimova Yulduz Botirbekovna. (2022). Obesity and the Functional State of the Cardiovascular System in Children. Eurasian Medical Research Periodical, 8, 48–51. Retrieved from https://geniusjournals.org/index.php/emrp/article/view/1486
Martynov AI, Avetyak AI, Akatova EV et al. Endothelial dysfunction and methods for its diagnosis. Russian Journal of Cardiology 2005; (4): 94-98.
Natochin YuV. Nephrology and fundamental science. Nephrology 2012; (16): 9-21.
Maratovna G. L., Ergashevna K. Z. Integrated clinical and metabolic evaluation of the condition of children with obesity and arterial hypertension //Достижения науки и образования. – 2020. – №. 8 (62). – С. 79-84.
Nikolaeva SN, Lebedeva EN, Vyalkova AA et al. Clinical assessment of blood levels of leptin and insulin in obese children. Modern Issues of Pediatrics 2007; (5):485-486
Smirnova NN, Kuprienko NB. Obesity nephropathy in pediatrics. Nephrology 2013 (6): 37-45
Smirnov AV, Shilov EM, Dobronravov VA. National Recommendations. Chronic kidney disease: basic principles of screening, diagnosis, prevention and treatment approaches. Nephrology 2012; (16): 89-115
Tareeva I.E. Mechanisms of progression of glomerulonephritis. Therapeutic Archive 1996; 6:5-10
Shvetsov M.Yu. Features of the syndrome of arterial hypertension in patients with lupus nephritis. Dissertation for the degree of candidate of medical sciences. - Moscow. - 1998 Avramoglu RK, Qiu W, Adeli K. «Mechanisms of metabolic dyslipidemia in insulin resistant states: Deregulation of hepatic and intestinal lipoprotein secretion. Front Biosci 2003; 8: d464-d476
Bagby SP. Obesity-initiated metabolic syndrome and the kidney: A recipe for Chronic kidney disease? J Am Soc Nephrol 2004; 15: 2775-2791
Bonnet F., Deprele C., Sassolas A. et al. Excessive body weight as a new independent risk factor for clinical and pathological progression in primary IgA-nephritis. Am J Kidney Dis 2001; 37 (4): 720-727
Calle E., Thun M., Petrelli J. et al. Body-mass index and mortality in a prospective cohort of U.S. adalts. B Engl J Med 1999; 7 (15):1097-1105
Carolin LA, Rodriguez MM. Obesity-related Nephropathy in Children. Pediatr Health 2009; 3(2): 141-153
Chagnac A, Herman M, Zingerman B et al. Obesityinduced glomerular hyperfiltration: its involvement in the pathogenesis of tubular sodium reabsorption. Nephrol Dial Transplant 2008; 23: 3946-
Chdek J, Adamczak М, Nieszporek T. еt al. Adipose Tisseu as an Endocrine Organ-A Nephrologistists Perspective. Obesity and kidney. Gunter Wolf 2006; 15 (1): 70-90.
Cortes P, Zhao X, Riser B, Narins RG: Regulation of glomerular volume in normal and partially nephrectomized rats. Am J Physiol 1996; 270: F356 -F370
Greenfield JR, Miller JW, Keogh JM et al. Modulation of blood pressure by central melanocortinergic pathways. NEJM 2009; 360: 44-52
De Simone G., Devereux R.B., Roman, et al. Relation of obesity and gender to left ventricular hypertrophy in normotensive and hypertensive adults. Hypertension 1994; 23: 600-606
Foster MC, Hwang SJ, Larson MG et al. Overweight, obesity, and the development of stage 3 CKD: the Framingham Heart Study. Am J Kidney Dis 2008; 52(1): 39-48. doi: 10.1053/j. ajkd.2008.03.003
Freemark M. Pediatric Obesity: Etiology, Pathogenesis, and Treatment. Humana Press, New York, 2010; 27-30
Hall JE. The kidney, hypertension, and obesity. Hypertension 2003; 41: 625-633
Henegar J. R., Bigler S. A., Henegar L. K., Tyagi S. C. and Hall J. E. Functional and Structural Changes in the Kidney in the Early Stages of Obesity J Am Soc Nephrol 2001; 12: 1211-1217
Hovi P, Andersson S, Raikkonen K et al. Ambulatory blood pressure in young adults with very low birth weight. J Pediatr 2010; 156: 54–59
Johnson D.W., Iabel N.M., Brown A.M. et al. The effect of obesity on renal transplantant outcomes. Transplantation 2002; 74: 675-681
Kambham N., Markowitz G.S., Valeri A.M., Lin J., DҐAgati V.D. Obesity-related glomerulopathy: An emerging epidemic. Kidney Int 2001; 59(4): 1498-1509
Kasiske BL, Crosson JT: Renal disease in patients with massive obesity. Arch Intern Med 1986; 146: 1105 -1109
Kato S, Nazneen A, Nakashima Y et al. Pathological influence of obesity on renal structural changes in chronic kidney disease. Clin Exp Nephrol 2009; 13: 332-340
Kiortsis, D.N. Management of Obesity-Induced Kidney Disease: A Critical Review of the Literature / D.N.Kiortsis, M.A. Christou // Obes Facts. - 2012 Nov. - Vol. 29; 5(6). - P.821-832. (Epub ahead of print).
Kuiper J.J. Effects of weight reduction and angiotensin-converting enzyme inhibition on IgA nephropathy-associated proteinuria. Nephron 1996; 74(2): 462-463
Landsberg L, Krieger DR: Obesity, metabolism, and the sympathetic nervous sytem. Am J Hypertens 1989; 2: 1255-1325
Levy D., Garrisson R.J., Savage D.D. et al. Left ventricular mass and incidence of coronary heart disease in an elderly cohort. Ann Intern Med 1989; 110: 101-107
Looker HC. Adiponectin concentrations are influenced by renal function and diabetes duration in Pima Indians with type 2 diabetes. J Clin Endocrinol Metab 2004; 89:4010-4017
Malyszko J, Bachorzewska-Gajewska H, Malyszko JS et al. Prevalence of Chronic Kidney Disease in Elderly Patients with Normal Serum Creatinine Levels Undergoing Percutaneous Coronary Interventions. Gerontol 2010; (56): 51-54.
Meier-Krieshce H.U., Vaghela M., Thambuganipalle R. et al. The effect of body index on long-trem renal allograft survival. Transplantation 1999; 68 (9): 1294-1297
Miyazaki Y, Cersosimo E, Triplitt C, DeFronzo RA. Rosiglitazone decreases albuminuria in type 2 diabetic patients. Kidney Int 2007; 72 (2):1367-1373. doi: 10.1038/sj.ki.5002516/
Naumnik B, Mysliwiec M. Renal consequences of obesity. Med Sci Monit 2010; 16(8): RA163-170
Neeraja KH, Markowitz GS, Anthony MV et al. Obesityrelated glomerulopathy: an emerging epidemic. Kidney Int 2001; 59: 1498-1509
Praga M., Hern_ndez E., Morales E. Clinical features and long-term outcome of obesity-associated focal segmental glomerulosclerosis. Nephrol Dial Transplant 2001; 15: 1790-1798
Rea DJ, Heimbach JK, Grande JP et al. Glomerular volume and renal histology in obese and non-obese living kidney donors. Kidney Int 2006; 70: 1636-1641
Serra A, Romero R, Lopez D et al. Renal injury in the extremely obese patients with normal renal function. Kidney Int 2008; 73: 947-955
Saxena A.K., Chopra R. Renal risk of an emerging «Epidemic» of obesity: the role of adipocyte-derived Factors. Dialysis and Transplantation 2004; 33: 11-20
Sharma A.M. Ожирение и риск сердечно сосудистых заболеваний: новые аспекты. 10th European Congress on Obesity, May 2000. Ожирение. Актуальные вопросы 2001; 5: 4-6/
Verani R.R. Obesity-associated FSGS: Pathologic features of lesion and relationship with cardiomegaly and hyperlipidemia. Am J Kidney Dis 1992; 20: 629-634
Vallon V, Blantz RC, Thomson S. Glomerular hyperfiltration and the salt paradox in early type 1 diabetes mellitus: a tubulocentric view. J Am Soc Nephrol 2003; 14:530-537
Vikse BE, Irgens LM, Leivestad T et al. Low birth weight increases risk for end stage renal disease. J Am Soc Nephrol 2008; 19:151–157
Weinberg J.M. Lipotoxicity. Kidney Int 2006; 70: 1560-1566
World Health Organization. Childhood overweight and obesity. http://www.who.int/dietphysicalactivity/childhood/en/ 2013
who.int [Internet]. Global Health Observatory (GHO) data. Overweight and obesity [cited 2017 Aug 9]. Available from: http:// www.who.int/entity/gho/ncd/risk_factors/overweight/en/.
Yamamoto S., Hanley E., Hahn A.B. et al. The impact of obesity in renal transplantation: An analysis of paired cadaver kidneys. Clin Transplant 2002; 16 (4):252-256.